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You are here: SCRI-UK

/Open Clinical Trials

Find a clinical trial

Open Clinical Trials

All of our clinical trials are listed on this page.  Click the arrow button on the right to see more details about that trial on ClinicalTrials.gov, a database of publicly and privately supported clinical trials around the world.

If you are a patient interested in taking part in a clinical trial, please speak to your doctor or cancer specialist.  If you are a doctor and have a patient you believe may be eligible for an ongoing clinical trial, please do not hesitate to contact us, or click here to access the Sarah Cannon Research Institute UK Patient Referral document.

Open and Recruiting

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Phase I

ATR protein kinase inhibitor

An Open-Label Study of the Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Profile of VX-803 as a Single Agent and in Combination With Carboplatin in Subjects With Advanced Solid Tumors or Lymphoma (REFMAL 385)

Adjuvant PD-L1

A Study comparing the efficacy and safety of atezolizumab (MPDL3280A) versus observation in participants with bladder cancer with risk features for recurrence after cystectomy (GU 125)

ASO- selective degrader of the KRAS primary transcript

A Phase I, Open-Label, Multicentre Dose-Escalation Study to Investigate the Safety and Pharmacokinetics of AZD4785 in Patients with Advanced Solid Tumours Where KRAS May Be an Important Driver of Tumour

Survival (REFMAL 484)

 

Colorectal

RAF/MEK/ERK pathway Inhibitors

A Multicenter, Randomized, Open-label, 3-Arm Phase 3 Study of Encorafenib +
Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional
5-Fluorouracil (5-FU)/Folinic Acid (FA) /Irinotecan (FOLFIRI)/Cetuximab with a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients with BRAF V600E-mutant Metastatic Colorectal Cancer (GI 236)

 

Diffuse Large B-cell Lymphoma

anti PD-L1 inhibitor

A Phase 1b Study to Evaluate the Safety and Efficacy of MEDI4736 as Monotherapy and in Combination with Tremelimumab or AZD9150 in Subjects with Relapsed or Refractory Diffuse Large B-cell Lymphoma (LYM112)

Glycoengineered antibody

A PHASE Ib/II STUDY EVALUATING THE SAFETY AND EFFICACY OF OBINUTUZUMAB IN COMBINATION WITH POLATUZUMAB VEDOTIN AND LENALIDOMIDE IN PATIENTS WITH RELAPSED OR REFRACTORY FOLLICULAR OR DIFFUSE LARGE B-CELL LYMPHOMA (LYM 113)

 

Melanoma

Autologous Tumor Infiltrating Lymphocytes

A Phase 2, Multicenter Study to Assess the Efficacy and Safety of Autologous Tumor Infiltrating Lymphocytes (LN-144) for Treatment of Patients with Metastatic Melanoma (MEL 56)

 

Prostate

Anti-PD-L1 Antibody

A PHASE III, MULTICENTER, RANDOMIZED STUDY OF ATEZOLIZUMAB (ANTI-PD-L1 ANTIBODY) IN COMBINATION WITH ENZALUTAMIDE VERSUS ENZALUTAMIDE ALONE IN PATIENTS WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER AFTER FAILURE OF AN ANDROGEN SYNTHESIS INHIBITOR AND FAILURE OF, INELIGIBILITY FOR, OR REFUSAL OF A TAXANE REGIMEN (GU 139)

Parp inhibitor

TRITON2: A Multicenter, Open-label Phase 2 Study of Rucaparib in Patients with Metastatic Castration-resistant Prostate Cancer Associated with Homologous Recombination Deficiency (GU 142)

Parp inhibitor

TRITON3: A Multicenter, Randomized, Open-label Phase 3 Study of Rucaparib versus Physician’s Choice of Therapy for Patients with Metastatic Castration-resistant Prostate Cancer Associated with Homologous Recombination Deficiency (GU 146)

 

Breast

Tyrosine kinase inhibitor vs anti-HER2 antibody

Phase 2 Randomized, Double-Blinded, Controlled Study of Tucatinib vs. Placebo in Combination with Capecitabine and Trastuzumab in Patients with Pretreated Unresectable Locally Advanced or Metastatic HER2+ Breast Carcinoma (BRE 271)

CDK4/6 inhibitor

Phase 1/2 Safety, Pharmacokinetic, and Antitumor Activity Study of G1T38 in
Combination with Fulvestrant in Patients with Hormone Receptor-Positive,
HER2-Negative Locally Advanced or Metastatic Breast Cancer after Endocrine Failure (BRE 282)

ATP-competitive inhibitor of CD K4 and CDK6

A Randomized, Open-Label, Phase 3 Study of Abemaciclib
Combined with Standard Adjuvant Endocrine Therapy versus
Standard Adjuvant Endocrine Therapy Alone in Patients with
High Risk, Node Positive, Early Stage, Hormone Receptor
Positive, Human Epidermal Receptor 2 Negative, Breast
Cancer (BRE 296)

 

Ovarian

WEE1 kinase inhibitor

A Multicentre Phase II Study of AZD1775 plus Chemotherapy in Patients
with Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary
Peritoneal Cancer (GYN49)

 

Lung

Potential CYP2C8 and CYP3A4 inhibitor

Phase III Randomized Clinical Trial of Lurbinectedin (PM01183)/Doxorubicin (DOX) versus Cyclophosphamide (CTX), Doxorubicin (DOX) and Vincristine (VCR) (CAV) or Topotecan as Treatment in Patients with Small-Cell Lung Cancer (SCLC) Who Failed One Prior Platinum-containing Line (ATLANTIS Trial) (LUN 337)

cMet RTK inhibitor

A phase II, multicentre, three-cohort study of oral cMET inhibitor INC280 in adult patients with EGFR wild-type (wt), advanced non-small cell lung cancer (NSCLC) who have received one or two prior lines of systemic therapy for advanced/metastatic disease (LUN 306)

 

Bladder

anti PD-L1 inhibitor

Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Multi-Centre, Multi-arm Phase 1b Study in patients with Muscle Invasive Bladder Cancer (MIBC) who have progressed on prior treatment (BISCAY) (GU 118)

 

Multiple Myeloma

FGFR inhibitor

An open-label, Dose-escalation and Dose-expansion, Phase I/ II Study of TAS-120, Evaluating the Safety, Tolerability, PK, Pharmacodynamic, and Antitumor Activity of TAS-120 in Patients with Advanced Solid Tumors or Multiple myeloma with and without FGF/FGFR-related abnormalities (REFMAL 340)

 

Pancreas

Recombinant human PH20 hyaluronidase enzyme conjugated to polyethylene glycol (PEG)

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of PEGylated Recombinant Human Hyaluronidase (PEGPH20) in Combination With nab Paclitaxel Plus Gemcitabine Compared With Placebo Plus nab Paclitaxel and Gemcitabine in Subjects with Hyaluronan-High Stage IV Previously Untreated Pancreatic Ductal Adenocarcinoma [GI 232]

 

Solid Tumours

anti-PD-L1 antibody +anti-cytotoxic T-lymphocyte antigen 4 antibody

An Open-Label, Multi-Centre, Safety Study of Fixed-Dose Durvalumab +
Tremelimumab Combination Therapy or Durvalumab Monotherapy in
Advanced Solid Malignancies (STRONG) (MULTI-25)

CHK1 Inhibitor

A Phase 1 Trial of SRA737 (a Chk1 Inhibitor) Administered Orally in Subjects with Advanced Cancer (REFMAL-522)

Monoclonal Antibody

A phase 1b/2 open-label study to evaluate safety, clinical activity, pharmacokinetics and pharmacodynamics of avelumab* (MSB0010718C) in combination with other cancer immunotherapies in patients with advances malignancies (REFMAL 434)

Chk1 Inhibitor

A Phase 1/2 Trial of Oral SRA737 (a Chk1 Inhibitor) Given in
Combination with Gemcitabine plus Cisplatin or Gemcitabine Alone
in Subjects with Advanced Cancer (REFMAL 523)

Anti-PD-1 Monoclonal Antibody

A Phase 1 Dose Escalation and Cohort Expansion Study of TSR-042, an anti-PD-1 Monoclonal Antibody, in Patients with Advanced Solid Tumors (MULTI-14)

Anti PD-L1A

A First-in-Human, Open-label, Phase 1/2 Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of JNJ-63723283, an Anti-PD-1 Monoclonal Antibody, in Subjects with Advanced Cancers (REFMAL 459)

PD L1 ProbodyTM therapeutic

An Open Label, Dose-Finding and Proof of Concept Study of the PD-L1 Probody™ Therapeutic, CX-072, as Monotherapy and in Combination with Yervoy® (Ipilimumab) or with Zelboraf® (Vemurafenib) in Subjects with Advanced or Recurrent Solid Tumours or Lymphomas (REFMAL 477)

HSP90 inhibitor

A Phase IA/IB Study evaluating TAS-116 in Patients with Advanced Solid Tumors (REFMAL 499)

Anti-PD-1 Monoclonal Antibody

A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination with Durvalumab versus Nivolumab Monotherapy in Subjects with Select Advanced Malignancies (REFMAL 391)

Anti-PD-1 Monoclonal Antibody

A Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of MGA012 in Patients with Advanced Solid Tumors (REFMAL 512)

Bruton's tyrosine kinase (Btk) inhibitor

Phase 1b/2 study in multiple gastrointestinal and genitourinary solid tumours [MULTI 08]

Tyrosine kinase inhibitor

An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients with Locally Advanced or Metastatic Solid Tumors that Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements [MULTI 05]

 

Cervix

Autologous Tumor Infiltrating Lymphocytes

A Phase 2, Multicenter Study to Evaluate the Efficacy and Safety Using Autologous
Tumor Infiltrating Lymphocytes (LN-145) in Patients with Recurrent, Metastatic or
Persistent Cervical Carcinoma (GYN 76)

Upcoming Studies

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CLL

Irreversible BTK Inhibitor

An International, Phase 3, Open-label, Randomized Study of BGB-3111 Compared with Bendamustine plus Rituximab in Patients with Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (CLL 44)

 

Solid Tumours

MEK Inhibitor

A Phase I, open-label study to determine the effect of
repeat dosing of trametinib on the pharmacokinetics of a
combined oral contraceptive (norethindrone plus ethinyl
estradiol) in female patients with solid tumors (REFMAL 491)

Probody-Tx

A Phase 1-2, Open-Label, Dose-Finding, Proof of Concept,
First-in-Human Study to Evaluate the Safety, Tolerability,
Pharmacokinetics, and Pharmacodynamics of CX-2009 in Adults
with Metastatic or Locally Advanced Unresectable Solid Tumors
(PROCLAIM-CX-2009) (REFMAL 509)

ATR kinase Inhibitor

A Modular Phase I, Open-Label, Multicentre Study to Assess the Safety,
Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of
Ascending Doses of AZD6738 in combination with Cytotoxic Chemotherapy
and/or DNA Damage Repair/Novel Anti-cancer Agents in Patients with
Advanced Solid Malignancies (REFMAL 561)

HER2-selective covalent inhibitor

A PHASE 1/2, OPEN-LABEL, MULTICENTER STUDY TO INVESTIGATE THE
SAFETY, PHARMACOKINETICS, AND EFFICACY OF TAS0728, AN ORAL COVALENT
BINDING INHIBITOR OF HER2, IN SUBJECTS WITH ADVANCED SOLID TUMORS WITH HER2 OR HER3 ABNORMALITIES (REFMAL 555)

 

Breast

ATR inhibitor/ WEE1 Inhibitor

A Phase II, Open Label, Randomised, Multi-centre Study to Assess the
Safety and Efficacy of Agents Targeting DNA Damage Repair in
Combination with Olaparib versus Olaparib Monotherapy in the Treatment
of Metastatic Triple Negative Breast Cancer Patients Stratified by
Alterations in Homologous Recombinant Repair (HRR)-related Genes
(including BRCA1/2) (BRE309)

 

Melanoma

Monoclonal Antibody/ IDO pathway inhibitor

A Phase 2/3 (Adaptive Design) Study of the
Concomitant Administration of Indoximod or
Placebo plus Pembrolizumab or Nivolumab in
Adult Patients with Unresectable Stage III or Stage
IV Malignant Melanoma (MEL 57)

 

Follicular Lymphoma

Irreversible BTK Inhibitor

An International, Phase 2, Open-Label, Randomized Study of BGB-3111 Combined with Obinutuzumab Compared With Obinutuzumab Monotherapy in Relapsed/Refractory Follicular Lymphoma (LYM 141)

Please also visit www.clinicaltrials.gov. Click here to access the SCRUK Patient Referral document.

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